Totah began her acting career in 2012 when she was cast as the “Lil’ Dictator” in the first production for AwesomenessTV. Beginning in 2013, she began appearing as Stuart Wooten, a boy with a crush on series regular Zuri Ross, in the Disney Channel Original Series Jessie. Totah has guest starred on the TV shows, New Girl, 2 Broke Girls, and Liv and Maddie.

Also in 2013, Totah was cast in a main role in the ABC comedy Back in the Game. In 2015, she was cast in 4 episodes of the sixth season Glee as the youngest member ever of the New Directions.

In 2016, Totah appeared in the film Other People, and received critical praise for her role with Variety, making her one of its Sundance Breakout Stars of the year. In October 2016, Deadline Hollywood reported that Totah would star in a new comedy for NBC that she helped develop where Totah was set to produce alongside executive producers Adam and Naomi Scott. In 2017, she appeared in the Netflix detective comedy Handsome: A Netflix Mystery Movie and the Marvel Studios film Spider Man: Homecoming.

In January 2017, Totah joined Adam Devine in the Disney feature film Magic Camp. In February 2017 Totah was cast as Michael Patel, the son of Mindy Kaling’s character, Priya Patel, in the new NBC comedy Champions, which was picked up to series in May 2017, and aired from March 8 to May 25, 2018 before being canceled. Totah was cast in a Saved by the Bell reboot for NBC’s streaming service Peacock, where she played the character of Lexi, a socially powerful cheerleader.

On August 20, 2018, Totah wrote an article published in Time in which she came out as a transgender woman.