Arrindell made her film debut playing a female leading role in the 1991 comedy Livin’ Large. She later went to appear in Trial by Jury (1994) and Clockers (1995). In 2006, Arrindell has appeared in three films, Big Momma’s House 2, The Second Chance and Madea’s Family Reunion. Ten years later, Arrindell went to star opposite Isaiah Washington in the thriller The Sin Seer.

On television, Arrindell had series regular role in the NBC sitcom In the House in 1995. She co-starred in a number of made-for-television movies, include A Lesson Before Dying (1999) alongside Don Cheadle and Cicely Tyson, Disappearing Acts (2000) starring Sanaa Lathan, The Wronged Man (2010) with Julia Ormond and Mahershala Ali, and The Immortal Life of Henrietta Lacks (2017) starring Oprah Winfrey. She also had guest starring roles on The Cosby Show, The Practice, The Steve Harvey Show, Drop Dead Diva, Law & Order: Special Victims Unit and Elementary. In 2017, she had a recurring role in the Bounce TV prime time soap opera Saints & Sinners.