He started his career as one of the most prominent industrialists of Pakistan. Nishat Textiles Mills was started in 1951 by his father and uncles. His father died one year after he returned from London after finishing his studies there in 1968. Mian Muhammad Mansha joined the family business in 1969 and eventually he split with his uncles and took over the family business. He was worth US$2.5 billion in 2013. Apart from making large acquisitions, he was simultaneously expanding his Nishat Textiles segment. Nishat Textiles Mills is Pakistan’s largest fabric manufacturing mills.

After 1979, Mansha set up Pakistan’s largest textile complex of seven factories in Nishatabad in the city of Faisalabad. In later years, another textile complex followed in Chunian near Lahore.

Mansha is currently on the board of various prominent institutes in Pakistan and is one of the most powerful and influential people in the country. He was awarded the Sitara-e-Imtiaz civil award by President of Pakistan Pervez Musharraf on 23 March 2004. One of Mansha’s companies, Nishat Textile Mills Limited, is the largest exporting entity in Pakistan. Mansha is also Sheikh and regularly leads Dhikr prayer in evenings.

In 2004, Mansha’s group and his preferred candidate were defeated by a margin of two votes in the All Pakistan Textile Mills Association (APTMA) elections. Mansha subsequently resigned from APTMA.

MCB Bank, in 2008, started a partnership with Maybank of Malaysia. Maybank now has a 20% share in MCB Bank. In 2009, Mian Muhammad Mansha, chairman of MCB Bank, said that his efforts were successful in continuing to bring foreign investment to Pakistan and that his bank had already brought 970 million U.S. dollars’ investment into the country from Malaysia following a deal with May Bank, Malaysia. He was selected for a special Lunch with the UK Financial Times newspaper. According to Forbes listings in 2010, he was the 937th richest person in the world and the richest person in Pakistan.

Mansha was named richest Pakistani in 2008 by Daily Pakistan with net worth of US$2.5 billion equivalent to Rs 200 billion at that time. In March 2010, Mansha was the first Pakistani making it to the Forbes billionaires list.