Bisson’s first major role was in the CBC’s critically acclaimed 1984 movie of the week Hockey Night, alongside Megan Follows and Rick Moranis. He starred in the Canadian television series Learning the Ropes from 1988–89. From 1994–97, he starred in the syndicated action series High Tide, co-starring Rick Springfield. He moved back from Los Angeles to Vancouver, British Columbia in 1998 when he was cast as the lead in CBC’S Nothing Too Good for a Cowboy. From 2000–04, he had a recurring role as attorney Brian Tedrow on the Showtime drama Soul Food.

He appeared on Falcon Beach in season two as well as in several Lifetime cable movies, such as Crazy for Christmas and I do (but I don’t), and the Disney Channel movie Genius. Bisson was a guest star on Flashpoint and starred in the television movies Brothers by Choice and Keshan. He appeared as Jon in all of the Roxy Hunter movies to date. Bisson is featured in a series of commercials for CIBC. He starred in the 2001 TV movie Loves Music, Loves to Dance based on the book by Mary Higgins Clark. He provided the voice of Ferdie in the children’s animated series Maxie’s World.

Starting on December 30, 2013, Bisson starred as a preschool teacher in The Adventures of Napkin Man on CBC Television.

Bisson was awarded the Fan’s Choice Award at the 2016 Canadian Screen Awards on March 13, 2016. Murdoch Mysteries was awarded the Canadian Screen Award Golden Screen Award for most watched, highest rated Canadian Drama in 2017 and 2018.

Bisson received the ACTRA Toronto Award of Excellence in 2017 for his lifetime of work.

Bisson played as Martin Bartell, in Hallmark Channel’s Aurora Teagarden Mysteries. He is introduced in “Three Bedrooms, One Corpse” as a CIA agent who moves to town, falls in love with Teagarden, and later dates her. Bisson left the series in 2018.