Arnault started his career in the advertising department of Louis Vuitton. In 2005, he was nominated to the board of directors and became director of communications in 2007.

In 2008, he was nominated to the editorial independence committee of Les Echos, a major French daily journal and in 2009 he made the Young Global Leader Honourees list.

In 2011, Arnault launched LVMH “Special Days”, the aim of which is to communicate about the expertise of the group. In 2013 he repeated the initiative and doubled the number of workshops open to the public, bringing the total to 42. The objective was to showcase the fact that the technical know-how was continually being passed on from skilled craftsmen unto the next talented generation.

Since 2011, he has been the CEO of Berluti and has worked to develop this LVMH brand through the opening of shops in California, Dubai and New York City. He hired the designer Alessandro Sartori in order to expand from being a colourful shoemaker household to a full-on menswear luxury brand name. Antoine Arnault has invested €100 million in developing the brand and its colourful footwear and classic modern fit clothes.

Since 2011, he has been in a relationship with the Russian model and philanthropist Natalia Vodianova, with whom he has two sons, Maxim, born 2 May 2014, and Roman, born 4 June 2016. Vodianova announced their engagement on 31 December 2019. The COVID-19 pandemic forced the cancellation of their 27 June 2020 wedding at Saint-Pierre d’Hautvillers Abbey, and the couple officially married on 21 June 2020 at a Paris registry office.

He created the “Core Values” campaign in 2012 featuring political figures (Mikhail Gorbachev), professional athletes (Muhammad Ali, Zinedine Zidane) and celebrities (Sean Connery, Francis Ford Coppola, Keith Richards).

Under his guidance, in three years Berluti’s business has grown from around $45 million to approximately $130 million a year in sales. In 2013, he became chairman of Loro Piana, global leader in high-end cashmere and other fabrics, following the acquisition of the brand by LVMH.

Arnault gave several speeches on the subject of the luxury industry and its future. During the Condé Nast International Luxury Conference in 2015, he highlighted consumers’ use of digital tools in daily life that encourages luxury brands to reach consumers through such technologies. But he stated that the luxury industry specific features lie in non-obsolescence and giving physical experience, as he underlined during his speech at Stanford University in 2004.