In 2014, Brielle made her television debut on NBC’s supernatural drama Grimm. In 2015, she appeared in TNT’s The Librarians and in 2016, she appeared in Fox’s short-lived Cooper Barrett’s Guide to Surviving Life.

In 2017, Brielle was cast as Sarika, “a career-driven student who’s constantly trying to do everything right and climb the ladder” in the NBC comedy A.P. Bio, which premiered in 2018.

Brielle is a close friend of Harley Quinn Smith, daughter of filmmaker Kevin Smith, with whom she co-starred in a project in 2017. The two starred together again in Jay and Silent Bob Reboot.

Brielle also stars as Lorna Reddy in Dead Girls Detective Agency, one of several new digital shows produced by NBCUniversal and Snap Inc. as part of their Snap Originals series. The first season began airing October 22, 2018, with a new episode available for viewing every day. Dead Girls Detective Agency was renewed for a third and fourth season and began airing new episodes on August 11, 2019.

In early 2019, Brielle joined Kevin Smith’s View Askewniverse, playing Jihad in Jay and Silent Bob Reboot, which was released on October 15 of that same year. According to Smith, the “plucky Jihad” is part of a girl gang not unlike the characters played by Shannon Elizabeth, Ali Larter, Jennifer Schwalbach, and Eliza Dushku; however, the girls are not international jewel thieves, and their specific grouping was set up as a commentary on youth and diversity being a common focal-point in Hollywood’s reboots and remakes.

On May 12, 2020, it was revealed that Brielle had landed the starring role of the sequel to Mallrats as Banner Bruce, daughter of Brodie Bruce (Jason Lee) and Rene Mosier (Shannen Doherty). This marks her second collaboration with Kevin Smith, who said, “I was so impressed with Aparna Brielle, I built [Twilight of the Mallrats] around her.”