In 2011, Griffin was cast as Trent Rogers on the USA Network drama Necessary Roughness.

In 2014, Deadline Hollywood announced that Griffin had joined the cast of the twenty-something ensemble drama Flipside being executive produced by Mark Feuerstein in conjunction with Wind Dancer Films.

He has appeared on many television shows including Castle, Jessie, Castle, Greek, Law & Order: Criminal Intent, Major Crimes, Mad Love, 90210, NCIS: LA, as well as the NBC television event Game of Your Life, where Griffin starred opposite Leah Thompson. Griffin can be seen in the 2016 made-for-TV movie Before You Say I Do.

In 2016, Griffin was cast in an episode of House of Lies; the episode was directed by Helen Hunt. He was previously directed by Hunt in the feature film Ride.

In 2016, Griffin joined several other Hollywood actors on the campaign trail as a vocal surrogate for former Secretary of State Hillary Clinton’s presidential campaign. Griffin travelled to several battleground states, giving speeches at campaign rallies in support of Clinton. The actor also appeared at various fundraisers and was among the celebrity hosts at the Los Angeles launch of Millennials for Hillary.

In 2017, Griffin gave the keynote speech outside of the Georgia State Capitol building at a rally designed to push back against Congressional efforts to repeal the Affordable Care Act.

In 2018, Griffin starred in the CW Seed reboot of the Warner Bros film Beerfest. Beerfest: Thirst for Victory is inspired by the 2006 Broken Lizard/Warner Bros cult classic film; it the first original film from the network. Griffin portrays the character Scott.

Griffin guest starred in Marvel’s Cloak & Dagger and the Mad About You Reboot, where he again worked with Helen Hunt. In 2020, it was announced that Griffin would be a part of the fifth season of Animal Kingdom on TNT, portraying the role of Lewis.