In 2005, she was featured on the New Order single “Jetstream”, taken from the band’s album Waiting for the Sirens’ Call. In 2009, Matronic performed on the glass harmonica at the New Museum in NYC in Auroville, a multimedia ritual tribute to an experimental community dedicated to the guru Sri Aurobindo. Ana appears as a guest vocalist on the Mark Ronson-produced track “Safe (In the Heat of the Moment)” from the December 21, 2010, release All You Need Is Now from the band Duran Duran.

Ana married her long-time boyfriend Seth Kirby in April 2010, at New York City Hall after having been together for seven years.

In 2012, Matronic appeared as an advisor on The Voice UK, pairing up to assist Jessie J. The following year, she served as commentator of the BBC Three broadcast of the Eurovision Song Contest 2013 semi-finals in Malmö, Sweden, for the United Kingdom, replacing Sara Cox. Matronic returned in 2014 as radio commentator on Radio 2 Eurovision, a pop-up DAB station, for the second semi-final of the Eurovision Song Contest 2014 in Copenhagen, Denmark.

Matronic appeared on Strictly Come Dancing: It Takes Two on November 15, 2013, alongside Jason Donovan and Jodie Prenger.

Her stage name is said to be due to “a deep and abiding love of robots”. In 2015, she penned a book entitled Robot Universe: Legendary Automatons and Androids from the Ancient World to the Distant Future; published by Sterling New York. She has a large tattoo on her right shoulder of bionic circuitry. She has a second tattoo on her ankle of a Celtic knot to signify her Irish roots.

She currently presents a weekly show on BBC Radio 2 from 00:00 to 02:00 on Sunday mornings. The show was titled Disco Devotion from April 2017. The final edition thus titled was broadcast on June 10, 2018, before the show changed its name to Dance Devotion.

She performed a live DJ set at Radio 2 Live in Hyde Park on September 10, 2018 and will host a New Year’s Eve 2018 show for the channel.

Ana is patron of UK charity Chrysalis which supports transgender people. In January 2019 she appeared on the BBC TV show Mastermind with Chrysalis as her chosen charity.