His movie, Otto; or Up with Dead People debuted at the 2008 Sundance Film Festival. L.A. Zombie was banned from the Melbourne International Film Festival in 2010 because, in the opinion of Australian censors, it would have been refused classification. However, the film was subsequently able to screen at OutTakes, a New Zealand lesbian and gay international film festival, in May 2011.

In March 2011, LaBruce directed a performance of Arnold Schoenberg’s opera Pierrot Lunaire at the Hebbel am Ufer Theatre in Berlin. This iteration of the opera included gender diversity, castration scenes and dildos, as well as portraying Pierrot as a transgender man. He subsequently also filmed this adaptation as the 2014 theatrical film Pierrot Lunaire.

Beginning with Gerontophilia in 2013, LaBruce dropped some of the more sexually explicit aspects of his filmmaking style. He retained his traditional interest in exploring sexual taboos, dramatizing an intergenerational relationship between a young man and a senior citizen, but opted to do so within a film that would be more palatable to a mainstream audience.

In 2018, LaBruce directed the short film Scotch Egg as part of Erika Lust’s XConfessions series. The short is about a Scottish gay man who has sex with a woman in a gay bar. LaBruce was inspired to create the film after reading a confession sent to XConfessions by a heterosexual woman who fantasized about going to a gay bar and having sex with a homosexual man.