Sampson appeared in Season 3 of Supernatural as the character Lisa Braedon, in the episode “The Kids Are Alright” in 2007. She reprised the role for the episode “Dream a Little Dream of Me” after showrunner Eric Kripke could not get the rights to use the character Jason Voorhees, the villain of the Friday the 13th horror film series. Sampson’s character was brought back in the fifth-season episodes “99 Problems” and “Swan Song” as setup to season six, in which she appeared in 11 episodes. Her final appearance was in the episode “Let It Bleed” (season 6, episode 21).

Sampson attended Randolph Academy for the Performing Arts, training in dance and theatre. In February 2012 she traveled to Bouvet Island in the South Atlantic Ocean, the most remote island on Earth, and climbed to the island’s summit while filming the “docu-fiction” movie Expedition for the Future.

In 2015, Sampson appeared in three episodes of Rookie Blue, a Canadian police drama television series starring Missy Peregrym and Gregory Smith, followed by eight episodes as Sophie Hale in the third season of the Canadian-British co-production Rogue, which stars Thandie Newton and Cole Hauser.

In 2016 the Global Television Network launched the TV series Private Eyes, in which Sampson stars as Angie Everett, an experienced private investigator who takes on an ex-hockey player, Matt Shade (Jason Priestley), as a junior partner.