Freeman finished the season hitting .341/.462/.640 with 13 home runs and 53 RBIs. He led the major leagues with 23 doubles and 51 runs scored. He was named the NL MVP, becoming the first Braves player to win the award since Chipper Jones in 1999. Freeman was also voted the Baseball Digest MLB Player of the Year, Baseball America Player of the Year, MLBPA Player’s Choice Player of the Year, and MLBPA Player’s Choice NL Outstanding Player.

He grew up a fan of the Los Angeles Angels. Freeman attended El Modena High School in Orange, California, where he was a third baseman and a pitcher. As a senior in 2007, Freeman hit for a .417 batting average and had a 6–1 win-loss record as a pitcher. The Orange County Register named him its 2007 player of the year. He signed a letter of intent with Cal State Fullerton.

Freeman was called up to the Braves on September 1, 2010, as part of the team’s September call-ups, and made his MLB debut that same day. On September 5, 2010, he got his first career MLB hit off of Florida Marlins pitcher Clay Hensley, and on September 21, 2010, he hit his first MLB home run off of Philadelphia Phillies pitcher Roy Halladay. He played 20 games with the Braves and batted .167. Freeman was not a part of the Braves’ playoff roster.

Freeman began the 2011 season as the starting first baseman for the Braves. After a slow start, his performance improved and he had been mentioned as a strong candidate for rookie of the year. On July 4, 2011, Freeman hit two home runs against the Colorado Rockies, for his first multi-home run game. Freeman was the first Braves rookie to reach 50 RBIs by July 18 since Hank Aaron accomplished this feat in 1954. He was the named NL rookie of the month for July; during that month, Freeman led all Major League rookies with 38 hits, a .362 batting average, and a.433 on-base percentage in July 27 games. He also led all NL rookies with six homers and 17 runs. His 18 RBIs tied for the most in the NL among rookies.

In 2012, Freeman had an NL-leading nine sacrifice flies along with batting .259 with 33 doubles, 23 home runs, and 94 RBI in 147 games played.

In 2013, Freeman was selected as a finalist for the 2013 Major League Baseball All-Star Game Final Vote, where he won with a record-setting total of 19.7 million fan votes, but was unable to play because of a thumb injury suffered three days prior to the game. Freeman finished the 2013 season with a .319 batting average, along with 23 homers and 109 RBI in 147 games played. He finished 5th on the National League Most Valuable Player award voting.

On February 4, 2014, Freeman agreed to an eight-year, $135 million extension. Freeman was named an All-Star for the second time in 2014, and played the last three innings of the game. He led the team in batting average and on base plus slugging percentage in 2014. Freeman also set a franchise record for innings played. During a game against the Philadelphia Phillies on June 27, 2014, Freeman hit a three-run homer off of Kyle Kendrick to left center field that was caught by broadcaster Tom McCarthy. Freeman finished the 2014 year by appearing in all 162 games batting .288 with 90 walks, 43 doubles, 18 home runs, and 78 RBI.

Freeman married Chelsea Goff in 2014. Goff appeared in a season 7 episode of Say Yes to the Dress: Atlanta. The couple had a son, Frederick Charles “Charlie” Freeman II in September 2016. The couple announced on August 28, 2020 that they are expecting twins in early 2021.

During a 2014 winter storm, Freeman was stuck in a traffic jam that was not moving. Freeman stayed stuck for hours until former teammate Chipper Jones arrived on his ATV and rescued Freeman successfully. In January 2016, the Atlanta Braves announced a “Chipper Rescues Freddie” bobblehead night for the upcoming season. This was used as a promotional night for the franchise.

On June 17, 2015, Freeman was listed as day-to-day with an injury to his right wrist originally sustained during a June 13 game against the New York Mets. He missed the June 18 game against the Boston Red Sox, ending a streak of 234 consecutive games played, which led the majors at the time. Freeman was officially placed on the 15-day disabled list on June 23, and received a platelet-rich plasma injection soon afterward. He was eligible for activation on July 3, but did not return to action until July 28, three days after he was removed from the disabled list. For the season, Freeman hit for a .276 batting average with 18 home runs and 66 RBIs in 118 games, his shortest season since 2011.

John Coppolella had assumed responsibility for the team’s transactions since the 2014–15 off-season, and played a large role in the Braves’ rebuild, having traded away many players. However, during the 2015–16 off-season, Coppolella repeatedly stated that he would not trade Freeman. At the beginning of the 2016 season, Freeman was expected to lead the team on the field, despite the wrist injury last year adversely affecting his off-season preparations. Freeman had a difficult start to the season, but began hitting well in June. On June 15, Freeman hit his first career cycle in a 9–8 victory against the Cincinnati Reds. He was named National League Player of the Week soon after that performance. Freeman recorded his first thirty home run season in 2016, on September 13, shortly after claiming his second Player of the Week award in the 2016 season. That day he also drove in the 500th run of his career. On September 29, Freeman’s 30-game hitting streak, which had begun on August 24, was halted with an 0–4 night against the Philadelphia Phillies. It had been a part of a larger 46-game run of getting on base, which also ended. During the penultimate week of the regular season, Freeman again was recognized as Player of the Week, and named the September National League Player of the Month at the end of the year. Overall in 2016, Freeman played 158 games with a .302 batting average, 43 doubles, 34 home runs, and 91 RBI. For the season, he led all major league hitters in line drive percentage (29.1%). He finished 6th on the National League Most Valuable Player award voting.

While rehabilitating his hand injury, Freeman stated in June 2017 that he offered to play third base upon his return, because his replacement at first base, Matt Adams, was hitting well. On July 1, Freeman appeared with the Triple-A Gwinnett Braves on a rehab assignment in which he played third base. Three days later, he returned to Atlanta, and started at third base against the Houston Astros. Freeman recorded his 1,000th career hit in a game against the Washington Nationals on July 6. Braves manager Brian Snitker stated in August that Freeman would no longer play third base regularly, as injuries to other players necessitated late-season promotions and allowed Freeman to return to first base.

Freeman underwent LASIK surgery in October 2017, to correct vision problems that had manifested since 2012. He was selected to his third All Star game as the National League’s starting first baseman. He also accepted an invitation to participate in the 2018 Home Run Derby.

At midseason, Freeman was selected the National League starter at first base in the 2019 Major League Baseball All-Star Game. The appearance was his second consecutive start in the game and his fourth All-Star Game selection overall.

In 2019 Freeman batted .295/.389/.549 with 38 home runs and 121 RBIs, and led NL hitters in line drive percentage (27.5%). Freeman and teammates Ronald Acuña Jr. and Ozzie Albies won the 2019 National League Silver Slugger Awards for first base, outfield, and second base, respectively. Freeman won the Wilson Defensive Player of the Year Award for the second consecutive season.

Freeman tested positive for COVID-19 in July 2020, before the season began. He was one of the only symptomatic MLB patients with high fever and loss of smell. He recovered in time to participate in some training camp activities, held before the shortened season’s Opening Day. Freeman hit his first career grand slam on September 4, in the second game of a doubleheader against the Washington Nationals off of pitcher Tanner Rainey. Two days later, he hit another grand slam, against Nationals pitcher Kyle Finnegan. On September 9, Freeman reached 1,500 career hits with a home run. During that same game against the Miami Marlins, he set a career high by driving in six runs.