Jones was married to her high school sweetheart between 1968 and 1974, and they had one child during that time. The relationship ended in divorce. Three years later Jones and her husband reconciled and had another child together in 1977. Just before her indictment, Jones married a 19-year-old nursing assistant. He filed for divorce a short time later.

In 1985, Jones was sentenced to 99 years in prison for killing 15-month-old Chelsea McClellan with succinylcholine. Later that year, she was sentenced to a concurrent term of 60 years in prison for nearly killing Rolando Santos with heparin.

As of May 2016, Jones was held at the Lane Murray Unit of the Texas Department of Criminal Justice. She had been scheduled for mandatory release in 2018 due to a Texas law meant to prevent prison overcrowding. To avoid this, Jones was indicted on May 25, 2017, for the murder of 11-month-old Joshua Sawyer. Nico LaHood, Bexar County District Attorney, stated that additional charges could be filed in the deaths of other children. Due to the mandatory early-release law covering Jones’ original convictions, she would otherwise have been released upon completion of a third of the original sentence. The new charges were filed to avoid her release. In April 2018, a judge in San Antonio denied a request to dismiss five new murder indictments against Jones. On 16 January 2020, Jones pleaded guilty to the murder of 11-month-old Joshua Sawyer on 12 December 1981 as part of a plea deal in which four other charges were dropped. She was sentenced to life in prison. She will not be eligible for parole until she is roughly 87 years old.