After he hit 29 homers for the White Sox in 1950, Zernial was sent to the Athletics in a trade that brought Minnie Miñoso to Chicago in 1951. That year Zernial led the league in home runs (33), runs batted in (129), extra base hits (68), and 17 assists in the outfield. In 1952 he hit 29 homers with 100 RBI, 42 and 108 in 1953.

Zernial was the first major leaguer to hit four home runs in the month of October during the regular season, since 1900, which he accomplished during a doubleheader on October 1, 1950. Ron Kittle would become the second player to do this in 1985.

Zernial and Al Zarilla teamed up in April 1951 to become the only players whose last names started with “Z” to play together in the same outfield. Zernial and Zarilla and played left and right field, respectively, as part of a White Sox outfield unit in four games before Zernial was traded to the Philadelphia A’s at the end of April.

Zernial was the first player to hit three home runs in the final game of a season, a record equalled by Dick Allen in 1968 and Evan Longoria and Dan Johnson in 2012.

Zernial was diagnosed with cancer in 1990. He died on January 20, 2011 at a Fresno hospice care center from the effects of congestive heart failure.

When the Oakland Athletics played the Philadelphia Phillies for the first time in interleague play in June 2003 at Veterans Stadium, the Phillies invited former Philadelphia A’s Eddie Joost and Zernial to the games and recognized them prior to the first game.