Considered a four-star recruit by Rivals.com, Collins was rated as the 22nd best cornerback prospect of his class. A member of Rivals.com Top 250. Rated the No. 249 prospect nationally and as the No. 22 cornerback by Rivals.com. Ranked No. 85 in the Press-Register Super Southeast120. Named to the Mississippi 6A First Team All-State by the Mississippi Association of Coaches. Named to the first team All-State by the Clarion Ledger. He announced his commitment to LSU on July 27, 2010, after receiving a scholarship offer from the school one week before at a summer camp hosted by LSU.

Collins red-shirted as a true freshman. In 2012, he played in 13 games, and started one against Texas A&M, where he recorded an interception. He finished the season with 30 tackles, two interceptions, and eight pass break-ups. In 2013, Collins played in all 13 games, while starting two. He recorded 22 tackles and added two pass break-ups. In 2014, he earned a starting position for the Tigers. He recorded 33 tackles, with two for loss, one interception and nine pass break-ups.

On May 9, 2015, the Falcons signed Collins to a four-year, $5.42 million contract with $2.88 million guaranteed and a signing bonus of $2.20 million.

Collins made his professional regular season debut in the Falcons’ season opener against the Philadelphia Eagles and made two solo tackles in the 26-24 victory on Monday Night Football. During a Week 7 matchup against the Tennessee Titans, Collins made his first career start in a 10–7 win. On November 8, 2015, he made his second career start and recorded a season-high five solo tackles during a 17-16 loss to the San Francisco 49ers. He finished his rookie season with 18 combined tackles in 16 games and two starts.

Collins entered the season as the third cornerback on the depth chart behind Alford and Trufant. On September 3, 2016, Collins was suspended for the first four games of the regular season for violating the NFL’s substance abuse policy.

On October 25, 2016, he appeared in his first game of the season after serving his four-game suspension and as the Falcons loss to the San Diego Chargers 33–30. He made his first start of the season in Week 9 after Desmond Trufant suffered a shoulder injury and was placed on injured-reserve. Collins recorded six solo tackles in a 24–15 loss to the Philadelphia Eagles. The next game, he made six combined tackles and a season-high three pass deflections during a 38–19 victory over the Arizona Cardinals. On December 24, 2016, he had a season-high recorded six solo tackles, two pass deflections, and intercepted Cam Newton for the first pick of his career, as the Falcons routed the Carolina Panthers 33–16. The following week, he recorded five solo tackles, three pass deflections, and intercepted Drew Brees in a 38–32 win over the New Orleans Saints.

On January 14, 2017, Collins appeared in his first career postseason game and recorded four solo tackles and a pass deflection in a 36–20 NFC Divisional game victory over the Seattle Seahawks. On January 22, 2017, he forced a key fumble after he stripped the ball away from Green Bay Packers’ fullback Aaron Ripkowski and recovered it, leading to a touchdown. He also made three combined tackles and a pass deflection as the Falcons routed the Green Bay Packers 44–21. In Super Bowl LI against the New England Patriots, Collins had a team-high eleven total tackles in the 34–28 loss in overtime.

Collins was suspended the first 10 games of the 2017 season for again violating the NFL’s policy on performing enhancing substances. On November 21, 2017, Collins was released by the Falcons after being reinstated from his suspension. On December 7, 2017, he was subsequently suspended for 4 more games for unspecified reasons.

On April 9, 2018, Collins was suspended for the fourth time in his career and received a ten-game suspension.

On November 15, 2018, Collins, after being reinstated from his suspension, was signed to the Indianapolis Colts practice squad. He was promoted to the active roster on December 29, 2018, but was waived two days later and re-signed to the practice squad. He signed a future/reserve contract on January 13, 2019.

On August 31, 2019, Collins was waived by the Colts and was signed to the practice squad the next day. He was released on September 30, 2019.

On November 22, 2019, Collins was selected by the Los Angeles Wildcats in the 2020 XFL Supplemental Draft.

On December 17, 2019, Collins was traded to the Tampa Bay Vipers in exchange for Arrion Springs. Collins was waived on March 3, 2020.