Von D married fellow tattoo artist Oliver Peck in 2003. They separated in August 2007, and finalized their divorce later that year.

She subsequently acquired her own TLC series, LA Ink, which chronicled her work at her tattoo shop, High Voltage Tattoo, in Hollywood, California. On the show, she broke the Guinness World Record of most tattoos given by a single person in 24 hours, with a total of 400. Accomplished in December 2007, it involved a Von D-designed logo for the city of Los Angeles, with proceeds going to the children’s-blindness charity Vitamin Angels. LA Ink ran four seasons, ending September 15, 2011; TLC announced the cancellation on August 18, 2011. Von D has publicly said that the cancellation was because she chose not to continue doing the show.

In July 2007, Von D decided to stop drinking after her usage of alcohol started to threaten her work. Von D recalled that “getting sober was not easy for me….I still clearly remember the physical pain from withdrawals, the profound desire to die, and the overwhelming sense of loneliness I felt that day that I decided to quit.”

In 2008, Von D created and launched a make-up line for Sephora. She has released new collections every year and has expanded her line to include fragrances. In 2012, through Sephora, her New American Beauty Art Tour benefitted the Art of Elysium charitable organization. In June 2016, she announced that all products in the line would be reformulated to be vegan. In August 2016, the line released a limited-edition lipstick named Project Chimps, with 20% of sales being donated to Project Chimps, an organization dedicated to providing care for retired research chimpanzees. Her makeup line later became mired in controversy after releasing a lipstick called “Selektion”. The word “Selektion” is considered widely controversial and inappropriate in its native Germany where it was the term used by the Nazis to decide who would be chosen to either be put to work or death upon arrival to the concentration camps. The fallout led to the lipstick being renamed “Beloved”. This choice is even more controversial with her being implicated in other anti-semitic acts. Von D fell under criticism again when she named a lipstick “Celebutard”, Sephora quickly pulled the lipstick from their stores and issued an apology.

Von D is the creator of the MusInk Tattoo Convention and Music Festival, which began in 2008. Musink is an all ages Tattoo, Music, and Art festival located in Southern California.

From February 2008 until January 2010, Von D dated Mötley Crüe bassist Nikki Sixx.

Her first book, High Voltage Tattoo, compiling her artworks and tattoos, with a foreword by Mötley Crüe’s Nikki Sixx, was released in January 2009 and reached #6 on The New York Times Best Seller list. Von D described the book as “not an autobiography, you know, ’cause I’m too young to do that. But this is just kind of like a picture-driven outline of my career as an artist. So, you see everything from my drawings when I was six to tattoos that have never before been seen.” Her second book, The Tattoo Chronicles, an illustrated diary following a year in her life, was released October 26, 2010, and reached #3 on The New York Times “Hardcover Advice & Misc.” best-seller list.

On September 2, 2010, Von D opened the art gallery and boutique Wonderland Gallery in the space next door to High Voltage Tattoo. She launched the clothing lines KVD Los Angeles and Kat Von D Los Angeles in the US and Canada in fall 2011, with the latter expanding internationally the following year.

She subsequently began dating motorcycle customizer, West Coast Choppers CEO, and reality TV personality Jesse James. On August 19, 2010, Von D confirmed media reports that she and James were dating, tweeting, “I think it’s pretty obvious that we’re dating.” Von D and James became engaged in January 2011. Von D announced that they had split in July 2011. However, in August 2011, Von D and James announced that their engagement was back on. In September 2011, Von D announced that she and James had broken up again. During her relationship with James he courted controversy when it became known that he was a collector of Nazi paraphernalia and was pictured in both a Nazi uniform and doing a Nazi salute. Von D was criticized for her continued involvement with James and lack of condemnation after the incident.

Kat Von D provided the female vocals to the song “Rosary Blue” on X, a 2012 studio album by the Finnish gothic rock band The 69 Eyes. In August 2013, she tweeted that Dave Grohl and producer Danny Lohner had finished two tracks of an album she had talked about recording as early as 2011.

In September 2012, Von D began dating Canadian music producer Joel Zimmerman, known professionally as Deadmau5, and gave him a star tattoo below his eye to match her own. They broke up in November 2012. However, on December 15, 2012, Zimmerman proposed to Von D over Twitter, and she accepted, becoming engaged to him. In June 2013, Von D announced that she and Zimmerman had ended their engagement. Von D cited Zimmerman’s alleged infidelity as the reason, which Zimmerman has denied.

In 2016 she recorded vocals for the electronic music duo, Prayers, on the song “Black Leather”, and appeared in the band’s video for the song.

Kat is vegan and promotes a cruelty-free makeup line. In 2016, she received Farm Sanctuary’s “Compassion in Action Award” for her work on behalf of animal rights.

In 2018, she collaborated with Rooney Mara, Sia, Sadie Sink and Joaquin Phoenix to narrate Chris Delforce’s animal rights documentary Dominion. For her contribution to the documentary, she was granted the 2018 Award of Excellence for Narration by Hollywood International Independent Documentary Awards.

Von D makes guest appearance on three songs on the 2018 album Alive in New Light by IAMX. She also appeared on synthwave band Gunship album Dark All Day in the song “Black Blood, Red Kiss”.

On February 21, 2018, Von D married Rafael Reyes, from the band Prayers. She announced her pregnancy on May 8, 2018. On November 29, Von D gave birth to their son Leafar Von Drachenberg Reyes.

On January 16 2020, Von D announced she had sold her namesake beauty brand to its parent company, Kendo Brands (a subsidiary of LVMH). The brand will be rebranded as “KVD Vegan Beauty”. According to the company the letters KVD now stand for “Kindness, Vegan Beauty, and Discovery (and Doing Good)”.