In 1997 he achieved notoriety as a member of the “Akyeame” hiplife duo, together with fellow Ghanaian Daniel Kofi Amoateng (under the stage name Okyeame Kofi). They recorded together the albums “Nyansapo” (“Witty Knot”, 1997), “Nkonsonkonson” (“Shackles”, 1998), “Ntoaso” (“Continuity”, 2000) and “Apam Foforo” (“New Testament”, 2002). He performed solo under his own record label One Mic Entertainment, in Accra since they parted in 2004. He also featured renowned Ghanaian highlife and hiplife artists as Daddy Lumba, Kojo Antwi and Ofori Amponsah.

Kwame released his first solo album “Boshe Ba” (Promised Child) in 2004, just after the breakup of the Akyeame band. He followed in 2008 with “Manwesem” (My Poetry) and in 2011 with “The Clinic”, launched at the Aphrodisiac Night Club in Accra. In 2012 he launched “The Versatile Show” (“Konfanko”).

For declaring himself B.R.A (Best Rapper Alive) in a song he recorded after winning Ghana Music Awards Artist of the Year award in 2009, Okyeame Kwame sparked a conflict with fellow Ghanaian rapper Obrafour, who saw himself more deserving. This resulted in one of the memorable feuds the Ghanaian music scene has seen, with Obrafour challenging Okyeame Kwame to a rap battle on the streets which was never honored. In 2011, after Obrafour had apologized for his actions Okyeame Kwame explained he declined Obrafour’s challenge because there was no need for it at the time, as winning Artist of the Year was vindicative enough.

Okyeame Kwame founded in 2009 the Okyeame Kwame Foundation, to raise public awareness on hepatitis B and to provide screening, prevention and education to mitigate the disease in Ghana, backed by MTN Ghana and the MDS-Lancet Laboratories. Periodic screening and vaccination campaigns are held throughout Ghana, attended by hundreds of people who receive free vaccines. In 2014, he staged the Celebrity Car Wash, an event including sports, games and photoshoots with celebrities in East Legon, to raise funds in support of his campaign to provide free vaccination to at least 1000 Ghanaian. The foundation has initiated and sponsored the construction of a hepatitis B treatment facility in Tamale.

Aside from musical performances, Kwame launched in 2012 “The Versatile Show”, produced by himself and performed biannually at the National Theatre, a theater show in which he blends his music with drama and poetry.

Kwame runs his own record label One Mic Entertainment and also Firm Bridges Communications, co-founded with his wife, and he is partner in the shoe manufacturing company Horseman Shoes. Due to his notoriety as a national icon in native Ghana, he became brand ambassador for MTN Group, GT Bank and Coca-Cola in Ghana, aside being appointed the public relations officer of the Musicians Union of Ghana (MUSIGA) from 2012 and the Ghana Music Right Owner (GHAMRO) in 2014.

From 2015, Kwame has also been appointed as ambassador for “My African Union, My Voice” campaign launched by the African Union in Addis Ababa as part of the activities of the “State of the Union” (SoTU) – a Pan-African Civil Society Organizations project which is currently being implemented in African countries including Ghana. The stated goals of the campaign are to help creating public awareness of the objectives of the African Union and to promote active citizen participation in the implementation of its protocols, conventions and policy decisions at the level of the member states of the Union.

Also, from 2015 he got appointed as ambassador for the Junior Boys Mentoring Conference, a youth-focused non-governmental initiative in Accra which seeks to equip young people with the necessary knowledge and skills that will enable them to tackle challenges as they come into contact with the outside world.

Okyeame Kwame in 2016 graduated from the University of Ghana with a Masters in Strategic Marketing. Prior to this, he was a BSc. holder in modern languages (Akan option) from the Kwame Nkrumah University of Science and Technology.

John Cranley, Mayor of the city of Cincinnati in Ohio USA on 21 November 2016 presented Okyeame Kwame with a Key to the City and declared 17 November each year as ‘Okyeame Kwame Day’ to solemnise his status as International Cultural Ambassador to the city.

Kwame was also honored on 3 February 2017 by the Chartered Institute of Marketing Ghana with the status of an associate co-opted member for his professional use of marketing in the creative arts.

At the 2017 Ghana Music Honours, he was given the best video honour for his song titled Small Small which features MzVee. Adding up, the rapper and philanthropist received a United States Presidential Volunteer Service Award. This award scheme is normally given to Americans but exception was made for the Ghanaian rapper dubbed (Kingdom Humanitarian Award) in recognition of his outstanding contribution towards kicking away hepatitis b.

The People’s Choice Practitioners Awards, organised by Media Men Ghana in April 2017 saw Okyeame receive the ‘Outstanding Health Ambassador’ honours presented to him by the Asantehene, his Majesty Otumfuo Osei Tutu II.

Again in 2017, Okyeame Kwame joined David Beckham, Hugh Jackman as UNICEF Super Dad Ambassadors. His selection as ambassador comes at the back of his recognition as a father with an enviable, amazing relationship with his children which had taken centre stage in the media over the years.