Driven by her ambition to play professionally, she sought out fellow musicians and other industry contacts in southern California with the idea of forming an all-woman rock band. In 1975, she met producer Kim Fowley, who gave her the phone number of another young musician in the area, guitarist Joan Jett. Joan and Sandy met shortly thereafter. The women subsequently played for Fowley, who agreed to help them find other female musicians to round out the band, most notably Lita Ford and Cherie Currie.

After four years of recording and touring the world, the Runaways disbanded in 1979. West made varied attempts to continue her career as a professional musician, playing with other acts in southern California, releasing a solo ep, The Beat is Back, and forming the Sandy West Band. None of these ventures produced significant income, so West was forced to spend most of her post-Runaways years working outside music. West later claimed that ex-Runaways’ manager/producer Kim Fowley had not paid the members of the band what they were entitled to. “I owe him my introduction to the music business but he’s also the reason I’m broke now,” West said.

In 2005, West, a heavy smoker, was diagnosed with lung cancer which later spread to her brain, and she died on October 21, 2006 at age 47. Former bandmate Joan Jett said, “We shared the dream of girls playing rock and roll. Sandy was an exuberant and powerful drummer,” adding, “I am overcome from the loss of my friend. I always told her we changed the world.” Cherie Currie said, “Sandy West was by far the greatest female drummer in the history of rock and roll. No one could compete or even come close to her, but the most important was her heart. Sandy West loved her fans, her friends and family almost to a fault. She would do absolutely anything for the people she loved. It will never be the same for me again to step on a stage, because Sandy West was the best and I will miss her forever.”

Sandy West was portrayed by actress Stella Maeve in the 2010 film The Runaways. The film also featured Kristen Stewart, Dakota Fanning and Scout Taylor-Compton, who portrayed Joan Jett, Cherie Currie and Lita Ford, respectively. During the audio commentary during the DVD extras, Joan Jett dedicated the film to her.