Kinberg married Mali Heled in a Jewish ceremony on July 26, 2001. They have two sons. The couple separated in 2014 and were divorced in early 2017. By November 4, 2019, Kinberg became engaged to writer Cleo Wade. They have a daughter, Memphis Love Kinberg, born January 20, 2020.

Kinberg was born in London, England to American parents Monica Menell-Kinberg and Jud Kinberg, a New York City-born writer and producer. From age six, he was raised in Los Angeles, California. He is Jewish. Kinberg graduated from Brentwood High School, and then from Brown University, Phi Beta Kappa, magna cum laude; in 2003 received his MFA from Columbia University School of the Arts, where he won the Zaki Gordon Fellowship for Screenwriting. While still in film school, Kinberg sold a pitch to Warner Brothers, then went on to write scripts for Disney, Sony, and DreamWorks, working with Steven Spielberg and Jerry Bruckheimer, among others. After finishing school, Kinberg moved to Hollywood, where his first screenwriting credit was a sequel to the hit action film XXX (2002), XXX: State of the Union (2005). His next screenwriting venture was the screenplay for Mr. & Mrs. Smith, directed by Doug Liman and starring Brad Pitt and Angelina Jolie. The script began as Kinberg’s thesis project for film school. Kinberg also wrote the pilot episode for a television adaptation of Mr. & Mrs. Smith for ABC TV. He also appears in the movie, in a scene with Brad Pitt.

Kinberg reunited with director Doug Liman for the film Jumper (2008). Kinberg wrote and produced the movie, which stars Samuel L. Jackson, Hayden Christensen, and Diane Lane. The following year, Kinberg was writer of Sherlock Holmes, directed by Guy Ritchie, starring Robert Downey, Jr. and Jude Law. In April 2010, his production company, Genre Films, signed a first-look deal with 20th Century Fox.

Kinberg was the producer of X-Men: First Class (2011), and both writer and producer of This Means War (2012). He was also co-screenwriter and an executive producer of the film Abraham Lincoln: Vampire Hunter in that same year. In 2013, Kinberg produced Elysium.

The following year, Kinberg was the writer and the producer of the film X-Men: Days of Future Past. That same year, he produced Let’s Be Cops. In 2015, Kinberg produced the Neill Blomkamp film Chappie and the live-action version of Cinderella at Disney. He also worked on Fantastic Four as writer and producer. His final film of the year was The Martian, directed by Ridley Scott.

He received a lifetime achievement award from the Saturn Awards in 2016.

He was named #61 on the list of 100 most powerful people in Hollywood by The Hollywood Reporter in 2016. The same year, The Hollywood Reporter named Kinberg as the highest-paid screenwriter in Hollywood with a record US$16 million for two X-Men scripts, and named him as one of the highest paid producers in Hollywood with US$40 million for Deadpool in their annual Hollywood Salaries issue.

In television, he is an executive producer on ABC network’s Designated Survivor starring Kiefer Sutherland, Legion created by Noah Hawley for FX, and The Gifted on Fox. He executive produced the third revival of the science fiction anthology series, The Twilight Zone which premiered on 2019.

In July 2019, it was announced that Kinberg and his production company Genre Films is leaving Fox after 20 years.