Holden was born in Cults, Aberdeen, Scotland, and grew up in Sugar Land, Texas, after moving there with his family at age 10. His father worked for Chevron Corporation in its human resources department. He played high school soccer in Houston for Awty International School. He graduated from Awty in 2003 and attended April 22, 2008 opening ceremony of the Awty athletic complex.

Holden was capped 11 times as a United States youth international at the U-20 level, scoring two goals, the first being on July 18, 2004 in a 2–2 home draw against Denmark U-20 in the 2004 Milk Cup in Northern Ireland. and the other on June 24, 2004 in a 1–2 defeat against Brazil U-20 in the Busan Four Nations International Youth Tournament. Early in 2007, Holden was called in to the U.S. U-23 squad for a camp in California and in December for a camp and trip to China to play matches against the China U-23 team. In July 2008, Holden was named to the U.S. squad competing in the 2008 Beijing Olympics. On August 7 he scored in the U.S.’s opening match, a 1–0 victory against Japan. In December 2008 Holden was called into a camp set to begin in January 2009 preceding a friendly against Sweden on January 24. He sustained a hip injury prior to the friendly and was forced to withdraw from camp.

After playing two seasons of college soccer at Clemson University, Holden signed with English club Sunderland in early 2005. On March 12, Holden was attacked outside a bar in Newcastle because he was a Sunderland player, leaving him with a fractured left eye socket, which prevented him from training with the club for two months. When Holden resumed training, he suffered an ankle injury that ruled him out for the rest of the season. Holden was released after his six-month stay having never played for Sunderland’s first team.

Holden returned to the United States to play in Major League Soccer with the Houston Dynamo for the 2006 season. He made his MLS debut on May 27, 2006, and scored his first professional goal on July 22, 2006, in a 1–1 home draw against New England. He appeared thirteen times in the 2006 regular season and twice as a substitute in Houston’s run to the MLS Cup 2006 championship. In the championship penalty shootout, Holden took the Dynamo’s second shot and scored to the top right corner.

Holden’s playing time increased in the 2007 season. He mostly started on the left wing when teammate Brad Davis went down with injury. In July, Holden scored goals on consecutive Thursday night games and added three assists in league play and another in SuperLiga play, as of July 25. In Holden’s final season with the Houston Dynamo, he finished the season with over 30 games played, 6 goals and 4 assists. He was named to Major League Soccer All-Star team and MLS Best XI and received the U.S. Soccer Humanitarian of the Year award.

Holden was named to the United States Gold Cup squad on June 25, 2009, as nearly all of the senior regulars were rested following the Confederations Cup. Holden scored a goal for the U.S. in his national team debut against Grenada on July 4, 2009. On July 11, 2009, Holden scored his second international goal against Haiti with a thirty-yard strike that tied the game in the ninety-second minute, and assisted the U.S.’s first goal in that match, which was scored by Davy Arnaud. Holden added two more assists in the 2–0 semi-final win against Honduras. Stuart was selected to the Gold Cup All-Tournament Team.

Holden was born in Scotland, and moved to the United States at the age of ten. Holden’s father lost a six-year battle with cancer in early 2009. His mother and sister still live in Houston. He has been an American citizen since 2006. Every game, Holden wears a Livestrong bracelet that belonged to his father, taping over it for its protection.

Having spent several weeks training in England following the end of the 2009 Major League Soccer season, Holden officially joined Premier League side Bolton Wanderers on January 25, 2010. He made his debut on February 24, 2010 in a 4–0 defeat against Tottenham Hotspur in the FA Cup, starting and playing the full ninety minutes. He made his first league appearance on February 27, 2010, playing the full 90 minutes in a 1–0 victory over Wolverhampton Wanderers. On September 30, 2010, he signed a new contract at Bolton, which would keep him at the club until 2013. He scored his first goal for Bolton away to Wolverhampton Wanderers on November 13, 2010.

During a friendly match on March 3, 2010, Nigel de Jong broke Holden’s leg, causing him to miss six weeks of soccer just months before the FIFA World Cup. After an intensive rehab, Holden proved his fitness by making it back on the field for Bolton Wanderer’s final home match of the season. On May 26, 2010, it was announced that Holden would be part of the 23-man roster for the U.S. National Team which played in the 2010 World Cup in South Africa and he played as a substitute in the opening 1–1 draw with England. He was part of the United States team that won their group ahead of England, Algeria and Slovenia.

On September 20, 2011, after six months out, Holden started and played the full ninety minutes against Aston Villa in the third round of the League Cup, but was then initially ruled out for a further six weeks as the club brought forward a routine follow up procedure. However, the procedure revealed cartilage damage, meaning Holden would be out for a further six months, missing the rest of the season. Later on in the season, Bolton Wanderers were relegated to the Championship after 11 years in the Premier League.

On June 22, 2012, Holden announced via his Twitter account that he was due to switch to the number 22 shirt after it had been vacated by Jussi Jääskeläinen. This was confirmed by the club when they released their squad numbers on July 5.

His return to action saw Holden receive another call-up to the US Men’s National team for World Cup Qualifying and the Gold Cup. However, after making 8 more appearances, it was confirmed that Holden had torn his anterior cruciate ligament in his right leg while playing for the United States in the CONCACAF Gold Cup final against Panama on June 29, 2013. In devastating news for Bolton Wanderers fans, it meant Holden would miss the majority of the 2013–14 season.

Holden joined fellow Championship Team Sheffield Wednesday on a months loan on March 28, 2013, mainly for match fitness after a series of injuries, and also to replace Sheffield Wednesday’s injured right midfielder Michail Antonio. and he made his debut two days later in the local derby at home to Barnsley. Holden played four times for Wednesday during his loan spell.

After two-and-a-half years without a national team appearance due to injuries, Holden was called up by Jurgen Klinsmann. In May 2013, he made his return, coming on as a substitute during the United States’ important match vs Panama in 2014 World Cup Qualifying. Later that summer, he was named to the 2013 CONCACAF Gold Cup squad that eventually went on to win the tournament. He appeared in 5 Gold Cup matches and scored in the opening match vs Belize. In the final vs Panama, Holden started the match, but was forced off through injury in the 23rd minute. It was later announced that he had torn his anterior cruciate ligament in the right knee and would require surgery, effectively ending his career with the national team.

After another comeback attempt, Holden returned to action in March 2014 in a reserve match vs Everton. In his first match back, his return from injury only lasted 23 minutes. It was later announced that Holden had re-injured the right knee and torn his anterior cruciate ligament for a 2nd time. It required another surgery which would set him back for another six to nine months.

Upon retiring from professional soccer, Holden pursued a career in TV and has become a voice of soccer in North America. He worked as an analyst for ESPN and NBC in 2014, before signing exclusively with Fox Sports 1 in 2016. Holden has also done work as a host, where he recently debuted a new series with Steve Nash called ‘Speak Responsibly’.

Holden first started working with Fox Sports in 2014, working on all of their marquee soccer properties (UEFA Champions League, MLS, FIFA, FA Cup, Europa League). He made a sharp rise in the TV business and within two years has established himself as FOX’s lead game analyst across multiple soccer properties. In April 2018, FOX announced that Holden would be their lead analyst for the 2018 FIFA World Cup in Russia. He partnered in the booth with John Strong and the pair travelled throughout Russia calling the tournament’s biggest games. Holden, at the age of 33, called the 2018 World Cup Final on July 15, 2018 featuring Croatia and France.

Having lived in and spent the majority of his childhood growing up in Scotland, Holden spoke with a Scottish accent up until the age of around 10, when, having emigrated to the U.S. with his family, he developed a pronounced Houstonian accent with which he still speaks to this day, despite having returned to live and work in the UK. He became engaged to model Karalyn West in March 2014, and the two got married in June 2015.

On January 4, 2016 it was announced that an American Group of investors, led by Robert Sarver, purchased a controlling stake in RCD Mallorca for $21 million. The ownership group included basketball icon, Steve Nash, and Stuart Holden. Holden and Nash’s journey as owners of the club has been well documented in their video podcast 2 Dads United, in which they discuss their roles and influence on the club. In 2018, RCD Mallorca were promoted to the 2nd division in Spain. In 2019, RCD Mallorca were promoted to Spain’s top division, La Liga. Holden and Nash are heavily involved on the soccer side and frequently visit their club on the island of Mallorca.

Holden, and his wife Karalyn, announced the birth of their first child, daughter Kennady, on February 3, 2016. They currently reside in Los Angeles, CA.

Holden’s brother, Euan Holden, was also a professional soccer player who last played for League Two club Bury. Euan was a viral sensation in 2018 when he became “#PlaneBae” – he had a blossoming romance that was filmed by a couple passengers on a plane. Holden said he was “upstaged” by his brother while he was covering the biggest tournament of his broadcasting career