Born in León, Guanajuato, Tania Lizardo decided to pursue a career in acting at age 18. She dropped out of Universidad La Salle where she had been studying architecture, and moved to Mexico City where she graduated from the Centro de Educación Artística (CEA). She made her television debut in the “María, pescadera” chapter of the TV series Mujeres asesinas in 2009. In 2011, producer José Alberto Castro, whom she had met while studying at CEA, gave her a role on the telenovela La que no podía amar. She has gone on to appear in other telenovelas such as Ni contigo ni sin ti, Un refugio para el amor, Por siempre mi amor, and Lo imperdonable.

In 2012, Lizardo made her feature film debut in the romantic comedy Viaje de generación [es].