In 1999, Khan started her career at Zee TV Network as an entertainment presenter and news reporter. She then hosted her own talk show interviewing celebrities from music and film, sports and politics. In 2001, she interviewed Bill Clinton a few months after he completed his second term as President of the United States.

She worked as a radio presenter for the BBC Asian Network, covering programmes like the Breakfast Show, Drive Time and The Album Chart. She was on air when news of the 2004 Indian Ocean earthquake and tsunami broke on Boxing Day in December 2004.

She then worked for PTV Prime as London correspondent where she reported the UK’s big news stories to a worldwide audience including the 7 July 2005 London bombings and the Ipswich serial murders in 2006.

She has hosted the annual BCA Gala Awards ceremony every year from 2007 to 2015. the Scottish Asian Business Awards in Glasgow in 2008 and 2009; and presented the Basis Soft Expo 2009 and an HIV/AIDS Conference in 2009, both in Dhaka. In 2010 and 2011, she hosted the Spice Times Restaurant Awards.

Khan was nominated for the Young Achiever of the Year honour at the Asian Woman Awards for Excellence in 2008.

On 6 September 2010, she joined the ITV Breakfast programme Daybreak after being headhunted from the BBC to be the sole news anchor covering all major world news stories as well as domestic, political and economic stories from the UK. She led the news teams through the 2011 London Riots, the uprisings in Egypt, Libya and Syria, and broke the news of the death of Osama bin Laden.

She left ITV News and morning TV in 2012 to pursue other opportunities in America after 15 years on UK television. From 2013 onwards, she was on US television as NBC Extra’s ‘Special Correspondent’ conducting celebrity interviews, and both entertainment and news stories ranging from the birth of the royal babies in the UK to red carpet coverage of major film premieres.

Khan was named Entrepreneur of the Year by the Lloyds Banking Group in 2014 for her leadership of mobile advertising company AdMaxim and several other technology starts in the Silicon Valley.

Khan is a keynote speaker on topics covering technology, media and advertising, and she spoke at the inaugural Periscope Summit in New York on 23 September 2015 on issues ranging from the impact of Periscope on both news organisations and user communities to highlighting the many positive uses of Periscope for charitable causes.

In January 2016, she was appointed CEO of Film company WR Entertainment, a publicly-traded company that had acquired the motion-picture rights to all 83 books in the Morgan Kane best selling book series which had sold over 20 million copies worldwide. In April 2016, she raised $3.5 million in working capital for the film company from the likes of Norwegian billionaires Bjørn Kjos and Arne Blystad. The first movie from the Morgan Kane film franchise was planned to start filming in 2016, but no news of any production dates has been announced yet.